Simulations of Antigenic Variability in Influenza A

Computational models of the immune system (IS) and pathogenic agents have several applications, such as theory testing and validation, or as a complement to first stages of drug trials. One possible application is the prediction of the lethality of new Influenza A strains, which are constantly created due to antigenic drift and shift. Here, we present several simulations of antigenic variability in Influenza A using an agent-based approach, where low level molecular antigen-antibody interactions are explicitly described. Antigenic drift and shift events are analyzed regarding the virulence of emergent strains against the IS. Results are discussed from a qualitative point of view taking into account recent and generally recognized immunology and influenza literature

Interoperability and Standards: The Way for Innovative Design in Networked Working Environments

Organised by: Cranfield UniversityIn today’s networked economy, strategic business partnerships and outsourcing has become the dominant paradigm where companies focus on core competencies and skills, as creative design, manufacturing, or selling. However, achieving seamless interoperability is an ongoing challenge these networks are facing, due to their distributed and heterogeneous nature. Part of the solution relies on adoption of standards for design and product data representation, but for sectors predominantly characterized by SMEs, such as the furniture sector, implementations need to be tailored to reduce costs. This paper recommends a set of best practices for the fast adoption of the ISO funStep standard modules and presents a framework that enables the usage of visualization data as a way to reduce costs in manufacturing and electronic catalogue design.Mori Seiki – The Machine Tool Compan